Indication: Sedation and analgesia in dogs and cats for clinical examinations, therapeutic procedures, minor surgery and minor dental manipulations. Also used as pre‑anesthetic medication for deep anesthesia in dogs.

Sedation and analgesia in dogs: Intramuscular injection at 500 μg/m² or intravenous injection at 375 μg/m². See table below.

Table 1 Dose Table for Sedation/Analgesia in Dogs

Body Weight (kg)	IV Dexmedetomidine 375 μg/m²		IM Dexmedetomidine 500 μg/m²
	μg/kg	ml	μg/kg	ml
2‑3	28.1	0.12	40.0	0.15
3‑4	25.0	0.15	35.0	0.20
4‑5	23.0	0.20	30.0	0.30
5‑10	19.6	0.29	25.0	0.40
10‑13	16.8	0.38	23.0	0.50
13‑15	15.7	0.44	21.0	0.60
15‑20	14.6	0.51	20.0	0.70
20‑25	13.4	0.60	18.0	0.80
25‑30	12.6	0.69	17.0	0.90
30‑33	12.0	0.75	16.0	1.00
33‑37	11.6	0.81	15.0	1.10
37‑45	11.0	0.90	14.5	1.20
45‑50	10.5	0.99	14.0	1.30
50‑55	10.1	1.06	13.5	1.40
55‑60	9.8	1.13	13.0	1.50
60‑65	9.5	1.19	12.8	1.60
65‑70	9.3	1.26	12.5	1.70
70‑80	9.0	1.35	12.3	1.80
＞80	8.7	1.42	12.0	1.90

 

Pre‑anesthetic medication in dogs: Intramuscular injection at 125 μg/m²‑375 μg/m². Pre‑anesthetic dose shall be determined by surgical procedure and severity, or according to anesthetic protocol. Please refer to table below for dose selection.

Table 2 Pre‑anesthetic Medication Dose Table for Dogs

Body Weight (kg)	IM Dexmedetomidine 125 μg/m²		IM Dexmedetomidine 375 μg/m²
	μg/kg	ml	μg/kg	ml
2‑3	9.4	0.04	28.1	0.12
3‑4	8.3	0.05	25.0	0.15
4‑5	7.7	0.07	23.0	0.20
5‑10	6.5	0.10	19.6	0.29
10‑13	5.6	0.13	16.8	0.38
13‑15	5.2	0.15	15.7	0.44
15‑20	4.9	0.17	14.6	0.51
20‑25	4.5	0.20	13.4	0.60
25‑30	4.2	0.23	12.6	0.69
30‑33	4.0	0.25	12.0	0.75
33‑37	3.9	0.27	11.6	0.81
37‑45	3.7	0.30	11.0	0.90
45‑50	3.5	0.33	10.5	0.99
50‑55	3.4	0.35	10.1	1.06
55‑60	3.3	0.38	9.8	1.13
60‑65	3.2	0.40	9.5	1.19
65‑70	3.1	0.42	9.3	1.26
70‑80	3.0	0.45	9.0	1.35
＞80	2.9	0.47	8.7	1.42

 

Sedation and analgesia in cats: Intramuscular injection at 40 μg/kg. Table below lists recommended doses of dexmedetomidine by cat body weight.

Table 3 Dose Table for Sedation/Analgesia in Cats:

Body Weight (kg)	IM Dexmedetomidine 40 μg/kg
	μg/kg	ml
2‑3	40	0.2
3‑4	40	0.3
4‑6	40	0.4
6‑7	40	0.5
7‑8	40	0.6
8‑10	40	0.7

Active ingredient: Dexmedetomidine hydrochloride

1. Dogs and cats shall fast for 12 hours prior to administration.Treated animals shall be kept warm under constant‑temperature environment during drug effect and recovery.
2. Ocular lubricant shall be used to prevent corneal desiccation caused by dark‑reflex‑induced eye‑opening suppression under sedation.
3. Rest dogs and cats for 15 minutes after injection. Sedative‑analgesic effect onset: 5‑15 min; peak effect: 15‑30 min post‑injection.
4. μg/kg dose decreases as body weight increases.
5. Contraindicated in dogs and cats with cardiovascular disorders, respiratory disorders, hepatic‑renal disorders, conditional shock induced by heat, cold or fatigue, severe debilitation or stress.
6. Contraindicated in animals hypersensitive to dexmedetomidine or any excipients (methylparaben / propylparaben).
7. Use cautiously with anticholinergic agents.
8. Safety data are unavailable for dogs younger than 16 weeks and cats younger than 12 weeks. Safety studies in male breeding animals have not been performed.
9. Safety in pregnant and lactating dogs and cats has not been established; use in gestation and lactation is not recommended.
10. Adverse reactions induced by this product may be reversed by atipamezole hydrochloride injection. After reversal of sedation‑analgesia, pain perception remains; continued pain management is required.
11. Exercise extreme caution when handling sedated dogs and cats. Any manipulation or sudden stimulus may trigger defensive‑aggressive behaviour even under deep‑apparent sedation.
12. Keep out of reach of children. Avoid direct human body contact during handling. In case of eye contact: flush continuously with clean water for minimum 15 minutes. In case of skin contact: wash thoroughly with soap and remove contaminated clothing. Local dermal/oral exposure or accidental human injection may cause sedation, hypotension, bradycardia. Seek immediate medical assistance if such exposure occurs.
13. For use under veterinary supervision only.
14. Do not freeze.

10 ml: 5 mg